Hydrochlorothiazide

Synonyms: hydrochlorothiazide, "Hypothiazide", "Esidrix", "Oretic", "Servithiazid", "Hydrosaluric", "Hidrotiazida", "Dichlotiazid", "Hydrochlorthiazide", "Hydrochlorothiazid", "Hydrodiuretic", "Thiuretic", "Maschitt", "Aquarills", "Newtolide", "Disalunil", "Diclotride", "Dichlotride", "Megadiuril", "Hypothiazid", "Aquarius", "Vetidrex", "Idrotiazide", "Esidrex", "Hydril", "Nefrix", "Hidril", "Drenol", "Hidrochlortiazid", "Chlorosulthiadil", "Hydro-Diuril", "Hydro-Aquil", "Jen-Diril", "Dihydrochlorothiazide", "Dihydrochlorothiazid", "Dihydrochlorothiazidum", "Urodiazin", "Neoflumen", "Hydrothide".

Source: Hydrochlorothiazide is used to treat high blood pressure (hypertension).

Identifiers:

IUPAC Name: 6-chloro-1,1-dioxo-3,4-dihydro-2H-1lambda6,2,4-benzothiadiazine-7-sulfonamide
CAS Number: 58-93-5
PubChem ID: 3639
InChiKey: JZUFKLXOESDKRF-UHFFFAOYSA-N
Canonical SMILES: C1NC2=CC(=C(C=C2S(=O)(=O)N1)S(=O)(=O)N)Cl

Structural Properties:

Molecular Formula: C₇H₈ClN₃O₄S₂
Molecular Weight: 297.7

Pharmacophore Features:

Number of bond donors: 3
Number of bond acceptors: 7
Number of atoms different from hydrogen: 17

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Evidence Supporting This Chemical as an Emerging Contaminant

Hermes, N., Jewell, K., Wick, A., & Ternes, T. (2018). Quantification of more than 150 micropollutants including transformation products in aqueous samples by liquid chromatography-tandem mass spectrometry using scheduled multiple reaction monitoring. Journal of Chromatography A, 1531, 64?73.

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2D-structure

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