Diclofenac

Synonyms: diclofenac, "Diclofenac acid", "Voltaren", "dichlofenac", "Diclofenacum", "Diclofenaco", "Voltarol", "Diclophenac", "2-(2-((2,6-Dichlorophenyl)amino)phenyl)acetic acid", "ProSorb-D", "Pennsaid", "Novapirina", "Diclofenac resinate", "Cataflam", "2-(2,6-Dichloroanilino)phenylacetic Acid", "2-((2,6-Dichlorophenyl)amino)benzeneacetic acid", "Solaraze", "HSDB 7234".

Source: Diclofenac is a widely used anti-inflammatory drug.

Identifiers:

IUPAC Name: 2-[2-(2,6-dichloroanilino)phenyl]acetic acid
CAS Number: 15307-86-5
PubChem ID: 3033
InChiKey: DCOPUUMXTXDBNB-UHFFFAOYSA-N
Canonical SMILES: C1=CC=C(C(=C1)CC(=O)O)NC2=C(C=CC=C2Cl)Cl

Structural Properties:

Molecular Formula: C₁₄H₁₁Cl₂NO₂
Molecular Weight: 296.1

Pharmacophore Features:

Number of bond donors: 2
Number of bond acceptors: 3
Number of atoms different from hydrogen: 19

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Evidence Supporting This Chemical as an Emerging Contaminant

Shuangshuang, C. A. O., Yanping, D. U. A. N., Yaoren, T. U., & Yali, P. U. (2018). Removal of emerging contaminant diclofenac from water using ferrite nanoparticles.

Lonappan, L., Brar, S. K., Das, R. K., Verma, M., & Surampalli, R. Y. (2016). Diclofenac and its transformation products: environmental occurrence and toxicity-a review. Environment international, 96, 127-138.

Aziz, H., Hikmat, K., Omer, K. M., Mahyar, A., Miessner, H., Mueller, S., & Moeller, D. (2019). Application of Photocatalytic Falling Film Reactor to Elucidate the Degradation Pathways of Pharmaceutical Diclofenac and Ibuprofen in Aqueous Solutions. Coatings, 9(8), 465.

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