Domperidone

Synonyms: domperidone, "Motilium", "Nauzelin", "Domperidonum", "Domperidona", "Motinorm", "Motillium", "R-33812", "4-(5-Chloro-2-oxo-1-benzimidazolinyl)-1-[3-(2-oxobenzimidazolinyl)propyl]piperidine", "Domperidone (Motilium)", "5-Chloro-1-(1-(3-(2-oxo-1-benzimidazolinyl)propyl)-4-piperidyl)-2-benzimidazolinone"

Source: Domperidone is a drug used globally for relieving nausea and vomiting.

Identifiers:

IUPAC Name: 6-chloro-3-[1-[3-(2-oxo-3H-benzimidazol-1-yl)propyl]piperidin-4-yl]-1H-benzimidazol-2-one
CAS Number: 57808-66-9
PubChem ID: 3151
InChiKey: FGXWKSZFVQUSTL-UHFFFAOYSA-N
Canonical SMILES: C1CN(CCC1N2C3=C(C=C(C=C3)Cl)NC2=O)CCCN4C5=CC=CC=C5NC4=O

Structural Properties:

Molecular Formula: C₂₂H₂₄ClN₅O₂
Molecular Weight: 425,900

Pharmacophore Features:

Number of bond donors: 2
Number of bond acceptors: 3
Number of atoms different from hydrogen: 30

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Evidence Supporting This Chemical as an Emerging Contaminant

Mailler, R., Gasperi, J., Patureau, D., Vulliet, E., Delgenes, N., Danel, A., ... & Chebbo, G. (2017). Fate of emerging and priority micropollutants during the sewage sludge treatment: Case study of Paris conurbation. Part 1: Contamination of the different types of sewage sludge. Waste management, 59, 379-393.

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